Blade II takes place a few months after the movie ends. Blade's mentor, Whistler, explains that a local gang is exchanging blood with some shady character. And, since shady blood dealers are never good news Whistler wants Blade to go investigate with his, well, blade.

The left analog stick controls forward and backward movement and camera rotation. You don't actually move Blade from side to side, rather you can turn him, as well as move him forward and backward. Because of this control scheme, there's no looking up and down. Blade can strafe, but doing so makes him move at a snail's pace, and Blade is fast in the movies. Blade can block with L2 and pull out his sword with R1. The D-Pad is mapped to weapons, so pressing down on it will choose a shotgun, and pressing right will have Blade pull out his glaive (if you've equipped it). Pressing X fires his weapon and pressing Square lets Blade jump, a move that really isn't used much in the game.
One of the game's big problems is its camera. Blade doesn't have the ability to look around, and if you're ever stuck fighting in a doorway, the camera will do all sorts of unpredictable things. The early levels are set in a parking garage, and you'll hear cars heading towards Blade while he's fighting some enemies. The problem is that you can't actually see them coming, and just hearing if they're to the left or to the right isn't good enough to dodge them. What I'm saying is that more than likely, most players will be hit by a car in the first couple of levels in the game, and it's really not their fault.
As mentioned above, Blade can pull his sword out to slice and dice his opponents, and doing so is the game's epiphany. It's bloodier than the movie and it rocks! You can cut off people's heads and arms, and stab them through the chest and neck. It sounds as cool as it is. Since the sword has to be earned and is only available for a limited time, this ultimately hurts the game, as it's really fun hacking with the sword. I guess the developers didn't want to make the title too easy, but I think letting players use the sword at any time would have made the game more like the movie.
Most of the combat in Blade II is hand-to-hand, and this also makes the game play suffer. Players are just pushing the right analog stick around and don't have any control over the actual moves Blade uses, just the direction of his attack. While this is a wonderful control scheme when enemies surround you, it's just not as good as letting the player decide to punch, kick, or throw. After a few levels, it feels as if you're just pushing the right analog stick around, and it certainly doesn't help that the enemies get faster and block more often later on in the game, when Blade's enhancements are meager in comparison.

Ouchie.